Intravenous administration of clonidine reduces intraocular pressure and alters ocular blood flow

Ocular rigidity, ocular pulse amplitude, and pulsatile ocular blood flow: the effect of intraocular pressure.

PURPOSE The purpose of this study was to characterize the pressure-volume relation in the living human eye, measure the ocular pulse amplitude (OPA), and calculate the corresponding pulsatile ocular blood flow (POBF) in a range of clinically relevant IOP levels. METHODS Fifty patients with cataract (50 eyes) were enrolled in the study. After cannulation of the anterior chamber, a computer-con...

Effects of topical clonidine versus brimonidine on choroidal blood flow and intraocular pressure during squatting.

PURPOSE Clonidine and brimonidine, two alpha-2 agonists, have been shown to reduce intraocular pressure (IOP) in patients with glaucoma. Little is known, however, about the exact role of alpha receptors in the control of ocular blood flow in the posterior pole of the eye. Hence, the study was conducted to investigate the effects of topical clonidine versus topical brimonidine on choroidal blood...

Comparison of Intraocular Pressure Fluctuations Measured by Goldmann Applanation Tonometer and Pulsatile Ocular Blood Flow Analyser

BACKGROUND Intraocular pressure (IOP) is the major known risk factor in glaucoma and the primer mover of the functional damage in glaucomatous patients but it is not a unique determinant of glaucomatous damage. Clinical assessment of glaucoma patients may not be a true reflection of overall IOP control. Evaluation of the effect of glaucoma medication is restricted by measurement of IOP as a dyn...

Mirtogenol® potentiates latanoprost in lowering intraocular pressure and improves ocular blood flow in asymptomatic subjects

PURPOSE The dietary supplement Mirtogenol((R)) was previously shown to lower elevated intraocular pressure (IOP). We here present the effects of this supplement on IOP in comparison as well as in combination with latanoprost eye drops. METHODS Seventy-nine patients with asymptomatic ocular hypertension were randomly assigned to three groups receiving either the supplement, or latanoprost eye ...

Exfoliation glaucoma: Studies on intraocular pressure, optic nerve head morphometry, and ocular blood flow